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Dalwai, Samir
- Stem Cell Therapy for Autism Spectrum Disorder and Other Developmental Disorders : What is the Recommendation?
Abstract Views :66 |
PDF Views:0
Authors
Affiliations
1 Fellowship in Developmental and Behavioral, New Horizons Child Development Centre, IN
2 Developmental and Behavioral Pediatrician, Founder Director, New Horizons Child Development Centre, IN
1 Fellowship in Developmental and Behavioral, New Horizons Child Development Centre, IN
2 Developmental and Behavioral Pediatrician, Founder Director, New Horizons Child Development Centre, IN
Source
The Indian Practitioner, Vol 76, No 5 (2023), Pagination: 26-28Abstract
Autism spectrum disorder (ASD) is a biologically-based neurodevelopmental disorder characterized by impairments in two major domains of development: social communication and social interaction, and restricted, repetitive patterns of behavior, interests, or activities. The severity of symptoms and impairments becomes evident when social demands exceed limited capacities. Over the past decade, there has been a significant increase in media attention, industrial growth, and patient interest in stem cell-based interventions. There is a rise in direct-to-consumer businesses offering stem cell “therapies” for various indications, despite a lack of evidence regarding their safety and efficacy. According to current regulatory guidelines, stem cell treatments, except for approved blood disorders such as hematopoietic disorders, are considered investigational and require approvals from the Central Drugs Standards Control Organization. Thus, using them outside the scope of clinical trials is not permissible. Some centers claim that “stem cell therapy” can “cure” and “treat” autism and promote and recommend its use. However, apart from causing financial strain, this procedure carries a high opportunity cost as it diverts valuable time and resources that could be better invested in evidence-based therapies for autism. Currently, the scientific evidence supporting the use of stem cells for treating ASD is limited. Therefore, it is insufficient to recommend their use in clinical practice. Future efforts should focus on developing standardized methods that generate robust data before considering their application in clinical settings.Keywords
Autism Spectrum Disorder, Stem Cell Therapy, Clinical Trials.
References
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- Dawson G, Sun JM, Baker J, Carpenter K, Compton S, Deaver M, Franz L, Heilbron N, Herold B, Horrigan J, Howard J, Kosinski A, Major S, Murias M, Page K, Prasad VK, Sabatos-DeVito M, Sanfilippo F, Sikich L, Simmons R, Song A, Vermeer S, Waters-Pick B, Troy J, Kurtzberg J. A Phase II Randomized Clinical Trial of the Safety and Efficacy of Intravenous Umbilical Cord Blood Infusion for Treatment of Children with Autism Spectrum Disorder. J Pediatr. 2020 Jul;222:164-173.e5.
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- Gains from Covid Lockdown: Moving to Online Platforms for Better Service and Outcome in Autism
Abstract Views :66 |
PDF Views:0
Authors
Affiliations
1 Developmental and Behavioral Pediatrician, Founder Director, New Horizons Child Development Centre, IN
2 Fellowship in Developmental and Behavioral, IN
3 New Horizons Child Development Centre, IN
1 Developmental and Behavioral Pediatrician, Founder Director, New Horizons Child Development Centre, IN
2 Fellowship in Developmental and Behavioral, IN
3 New Horizons Child Development Centre, IN
Source
The Indian Practitioner, Vol 76, No 2 (2023), Pagination: 6-10Abstract
In the gloom of uncertainties, the COVID era most certainly has necessitated a bevy of transitions in the healthcare domain. Moving on with these metamorphoses, the world is moving onto the virtual platform for healthcare, accepting it as one of the primary means of availing healthcare services. The effect of the pandemic on children with special needs, especially on children with Autism Spectrum Disorder (ASD) has been of utmost concern since then. The aim of this program was to help overcome the challenges faced by families in accessing developmental pediatrician led multidisciplinary treatment for ASD (e.g., in smaller cities etc.) and delivering an intervention program in the home and community. With the virtual format quickly gaining traction, theE-nable Parent Coaching program was thus introduced, facilitating improvement in developmental trajectories and functional outcomes in children with Autism Spectrum Disorder (ASD) with complex neurodevelopmental profiles across the globe through an outcome- based, individualized, interdisciplinary approach based on the Theory of interaction. Five cases of children with ASD with varying severity have been reported that illustrate the functional improvement across various domains within months of the program; much in contrast to long term therapies often failing to deliver the desired clinical outcomes. Our findings revealed resolution of co-morbidities without the role of exogenous pharmacotherapy or long standing intensive behavioural interventions. The paradigm shift from conventional therapies to targeted goal- oriented interventions solely based on meticulously designed and structured parent coaching based on the Theory of Social Interaction has shown remarkable clinical outcomes.Keywords
Autism Spectrum Disorder, COVID, Interventions, Online, Parent.References
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